MORPHOLOGICAL CHARACTERISTICS OF CHANGES
IN THE ESOPHAGUS BURN AREA AS A RESULT OF MEXIDOL THERAPY 

Nikol'skiy Valeriy Isaakovich, Doctor of medical sciences, professor, sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), pmisurg@gmail.com
Klimashevich Aleksandr Vladimirovich, Candidate of medical sciences, associate professor, sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), klimashevich78@mail.ru
Fedorova Mariya Gennad'evna, Candidate of medical sciences, associate professor, sub-department of clinical morphology and forensic medicine with a course of oncology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), fedorovamerry@gmail.com
Shabrov Aleksandr Valer'evich, Resident, sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), alexundead12@yandex.ru
Averkin Nikita Sergeevich, Student, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), averkin.n@pochta.ru  

617-89.844 

Background. The aim of the study is to define rationality of mexidol use in treatment of chemical burns of the esophagus.
Materials and methods. 30 sexually mature rabbits of "Chinchilla" breed were subject to esophagus chemical burn simulation. Morphological changes in the esophageal wall burn area were evaluated in dynamics. The authors singled out a control and an experimental group, the experimental group was treated by mexidol.
Results. It was found that the experimental group in the burn area features an early relief of inflammation, the processes of connective tissue and epithelium development are more active.
Conclusions. When applying mexidol, the signs of exudative inflammation stop being detected earlier in the samples, blood vessels and epithelium are also formed earlier. Burn regeneration in the course of mexidol therapy progresses more actively than natural healing. 

esophagus burn, mexidol, experiment. 

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